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Walker is working with a commercial outfit in California to compare all three girls entire genome sequences the exome plus the other 98% of DNA code, which is thought to be responsible for regulating the expression of protein-coding genes.
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Ageing, he thought, comes about because this developmental programme, this constant change, never turns off. From birth until puberty, change is crucial: we need it to grow and mature. After we ve matured, however, our adult bodies don t need change, but rather maintenance. If you ve built the perfect house, you would want to stop adding bricks at a certain point, Walker says. When you ve built a perfect body, you d want to stop screwing around with it. But that s not how evolution works. Because natural selection cannot influence traits that show up after we have passed on our genes, we never evolved a stop switch for development, Walker says. So we keep adding bricks to the house. At first this doesn t cause much damage a sagging roof here, a broken window there. But eventually the foundation can t sustain the additions, and the house topples. This, Walker says, is ageing.
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